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Procedure of Overdose In case of overdose, priorities would be the reestablishment of a patent airway and guarded airway and establishment of assisted or controlled ventilation, if needed. Hire other supportive actions (including oxygen and vasopressors) within the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require Innovative lifestyle-support approaches. The opioid antagonists, naloxone or nalmefene are distinct antidotes to respiratory depression resulting from opioid overdose. For clinically substantial respiratory or circulatory depression secondary to hydromorphone overdose, administer an opioid antagonist. Opioid antagonists really should not be administered from the absence of clinically significant respiratory or circulatory depression secondary to hydromorphone overdose. Since the period of opioid reversal is predicted to be less than the duration of hydromorphone in DILAUDID INJECTION, very carefully keep track of the individual until spontaneous respiration is reliably reestablished.
Usage of opioid analgesics for an extended time frame in the course of pregnancy for health care or nonmedical purposes may lead to physical dependence during the neonate and neonatal opioid withdrawal syndrome shortly right after beginning.
If this SPL contains inactivated NDCs outlined via the FDA initiated compliance action, They are going to be specified as such.
Opioid antagonists should not be administered inside the absence of clinically significant respiratory or circulatory despair secondary to hydromorphone overdose.
Dilaudid really should be Employed in pregnant Gals provided that the likely advantage justifies the likely threat to the fetus or breastfeeding toddler; the drug should not be used for labor or shipping; Expecting Women of all ages getting the medication will usually trigger the fetus/infant being dependent on opioids and likely will produce other consequences over the infant. There aren't any Dilaudid scientific tests on pediatric individuals. More Information and facts
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Hydromorphone leads to a reduction in motility connected with a rise in smooth muscle tone during the antrum from the stomach and duodenum. Digestion of food items inside the small intestine is delayed and propulsive contractions are lessened.
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Lots of acute pain problems (e.g., the pain that happens with several surgical strategies or acute musculoskeletal accidents) demand no quite a lot of times of the opioid analgesic. Clinical tips on opioid prescribing for a few acute pain ailments are available.
To scale back the potential risk of respiratory despair, right dosing and titration of DILAUDID INJECTION is important [see DOSAGE AND ADMINISTRATION]. Overestimating the DILAUDID INJECTION dosage when converting patients from One more opioid products may result in a fatal overdose with the very first dose.
you should know that this medication might minimize fertility in men and girls. Talk with your medical doctor regarding the hazards of utilizing hydromorphone injection.